Activation and localization of cartilage-derived morphogenetic protein-1 at the site of ossification of the ligamentum flavum
T. Nakase, K. Ariga, K. Yonenobu, N. Tsumaki, F. Luyten, Y. Mukai, I. Sato, H. Yoshikawa
June 2001, Volume 10, Issue 4, pp 289 - 294 SSE Orthobiology Award Read Full Article 10.1007/s005860100307
First Online: 23 June 2001
Localization and expression of cartilage-derived morphogenetic protein (CDMP)-1 in tissues at the site of ossification of the ligamentum flavum (OLF) were examined by immunohistochemistry and in situ hybridization. The CDMP-1 protein and messenger ribonucleic acid (mRNA) were localized in spindle-shaped cells and chondrocytes in the OLF tissues. CDMP-1 was not detected in cells in non-ossified sites. These data indicate that CDMP-1 is locally activated and localized in spindle-shaped cells and chondrocytes at the site of OLF. Given the previously reported promoting action of CDMP-1 for chondrogenesis, the current results suggest that CDMP-1 may be involved in the progression of OLF, leading to the narrowing of spinal canal and thus causing severe clinical manifestations.
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