T. Nakase, K. Ariga, K. Yonenobu, N. Tsumaki, F. Luyten, Y. Mukai, I. Sato, H. Yoshikawa


June 2001, Volume 10, Issue 4, pp 289 - 294 SSE Orthobiology Award Read Full Article 10.1007/s005860100307

First Online: 23 June 2001

Localization and expression of cartilage-derived morphogenetic protein (CDMP)-1 in tissues at the site of ossification of the ligamentum flavum (OLF) were examined by immunohistochemistry and in situ hybridization. The CDMP-1 protein and messenger ribonucleic acid (mRNA) were localized in spindle-shaped cells and chondrocytes in the OLF tissues. CDMP-1 was not detected in cells in non-ossified sites. These data indicate that CDMP-1 is locally activated and localized in spindle-shaped cells and chondrocytes at the site of OLF. Given the previously reported promoting action of CDMP-1 for chondrogenesis, the current results suggest that CDMP-1 may be involved in the progression of OLF, leading to the narrowing of spinal canal and thus causing severe clinical manifestations.


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