D. G. Marchesi


October 2000, Volume 9, Issue 5, pp 372 - 378 Review Read Full Article 10.1007/s005860000203

First Online: 04 October 2000

Vertebral arthrodesis is one of the most commonly performed, yet incompletely understood, procedures in spinal surgery. Despite major progress in internal fixation techniques, the high rate of non-unions indicates that physiologic, biologic and molecular events that are crucial to this process are not well known. This article will analyze the general biology of bone regeneration, and particularly discuss the properties and use of various bone graft materials and graft substitutes.


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