Jiahui Zhang, Xiaoying Xing, Qizheng Wang, Yongye Chen, Huishu Yuan, Ning Lang

June 2022, pp 1 - 9 Original Article Read Full Article 10.1007/s00586-022-07269-w

First Online: 01 June 2022


Quantitative comparison of diffusion parameters from various models of diffusion-weighted (DWI) and diffusion kurtosis (DKI) imaging for distinguishing spinal metastases and chordomas.


DWI and DKI examinations were performed in 31 and 13 cases of spinal metastases and chordomas, respectively. DWI derived apparent diffusion coefficient (ADC), true diffusion coefficient (D), pseudo diffusion coefficient (D*), perfusion fraction (f), water molecular distributed diffusion coefficient (DDC), and intravoxel water diffusion heterogeneity (α). DKI derived mean diffusivity (MD) and mean kurtosis (MK). Independent sample t-testing compared statistical differences among parameters. Sensitivity, specificity, and area under the receiver operating characteristic (ROC) curve were determined. Pearson correlation analysis evaluated the parameters’ correlations.


ADC, D, f, DDC, α, and MD were significantly lower in spinal metastases than chordomas (all P 


Monoexponential, biexponential, and stretched-exponential models of DWI and DKI can potentially differentiate spinal metastases and chordomas. D combined with f and α performed best.

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