Nicola Giampaolini, Massimo Berdini, Marco Rotini, Rosa Palmisani, Nicola Specchia, Monia Martiniani

January 2022, pp 1 - 12 Original Article Read Full Article 10.1007/s00586-021-07072-z

First Online: 15 January 2022


Pyogenic spondylodiscitis is a relatively rare spinal disease; non-specific spondylodiscitis (NSS) cases are increasing. This study aims to identify if changes of inflammatory markers under antibiotic therapy can be used to determine which NSS patients can benefit from surgical indication earlier than others.


Two groups of patients with NSS were examined. Group A underwent surgery, while Group B was treated conservatively. Group B was also subdivided in patients undergoing antibiotic therapy for > 6 weeks (B1) and


There were no differences (P = 0.06) in reduction in ESR at 4 weeks between two main groups. A reduction in CRP, with


The surgical treatment should be considered for patients who, after 4 weeks of conservative therapy, do not show a reduction in the ESR 

The comparison between groups underwent surgically and those treated conservatively showed a reduction in the CRP at 4 weeks and better VAS for pain at 3 months in Group A.

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