Sohrab Salimi, Hamid Reza Khayat Kashani, Shirzad Azhari, Sohrab Sadeghi, Siavash Sheikhghomy, Poorya paryan, Maryam KhayatKashani
February 2022, Volume 31, Issue 2, pp 454 - 460 Original Article Read Full Article 10.1007/s00586-021-07050-5
First Online: 09 November 2021
This prospective randomized controlled trial hypothesizes that intra wound vancomycin reduces postoperative infection.
In this RCT study, the patients were randomly divided into two groups of treatment and control. In the treatment group, 1–2 g of intra wound vancomycin was used, and no drug was used for the control group. SSI and the type of microorganism causing postoperative infection were assessed at a three-month follow-up. Factors affecting postoperative infection such as age, sex, site of operation, surgical levels, and risk factors affecting postoperative infection, such as diabetes, blood pressure, ischemic heart disease, smoking, blood transfusion, BMI, neurologic deficit, CSF leakage, UTI, COPD and surgery time were examined in two groups.
In this study, 375 patients, including 187patients in the treatment group and 188 patients in the control group, were studied. Among the patients, 228 had surgery without instrumentation, and 147 had surgery with instrumentation. There were 12 cases of SSI in the treatment group and 11 in the control group, and there was no statistically significant difference between the two groups. There was no difference between the two groups with and without instrumentation in the evaluation of postoperative infection. In the subgroups with and without instruments, there was no significant difference between treatment and control groups. Due to the microorganism causing the infection, gram-negative bacteria were more common in the treatment group.
Intra-wound vancomycin has no effect on SSI; in addition, it can increase the rate of gram-negative infections.
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