Yongye Chen, Enlong Zhang, Qizheng Wang, Huishu Yuan, Hongqing Zhuang, Ning Lang

October 2021, Volume 30, Issue 10, pp 2867 - 2873 Original Article Read Full Article 10.1007/s00586-021-06742-2

First Online: 01 March 2021


The present study aimed to explore the value of DCE-MRI to evaluate the early efficacy of CyberKnife stereotactic radiosurgery in patients with symptomatic vertebral hemangioma (SVH).


A retrospective analysis of patients with spinal SVH who underwent CyberKnife stereotactic radiosurgery from January 2017 to August 2019 was performed. All patients underwent DCE-MRI before treatment and three months after treatment. The parameters included volume transfer constant (Ktrans), transfer rate constant (Kep), and extravascular extracellular space volume fraction (Ve).


A total of 11 patients (11 lesions) were included. After treatment, six patients (54.5%) had a partial response, five patients (45.4%) had stable disease, and three patients (27.3%) presented with reossification. Ktrans and Kep decreased significantly in the third month after treatment (p = 0.003 and p = 0.026, respectively). ΔKtrans was −46.23% (range, −87.37 to −23.78%), and ΔKep was −36.18% (range, −85.62 to 94.40%). The change in Ve was not statistically significant (p = 0.213), and ΔVe was −28.01% (range, −58.24 to 54.76%).


DCE-MRI parameters Ktrans and Kep change significantly after CyberKnife stereotactic radiosurgery for SVH. Thus, DCE-MRI may be of value in determining the early efficacy of CyberKnife stereotactic radiosurgery.

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