Alessandra Colombini, Fabio Galbusera, Maria Cristina Cortese, Enrico Gallazzi, Marco Viganò, Domenico Albano, Sabina Cauci, Luca Maria Sconfienza, Marco Brayda-Bruno

August 2021, Volume 30, Issue 8, pp 2231 - 2237 Original Article Read Full Article 10.1007/s00586-021-06719-1

First Online: 16 January 2021


To detect the associations between the degree of the endplate (EP) lesions with the presence of risk factors, biochemical and genetic markers previously observed in low back pain (LBP) patients with EP defects in comparison with hernia/discopathy patients and healthy controls.


In this observational retrospective study, T2-weighted sagittal MRI images (n = 223 LBP patients) were scored for EP lesions by two independent observers. Total MRI score and number of affected levels (L1/L2–L5/S1) have been considered for the correlation with demographic, behavioral, clinical, biochemical (25(OH)D, CTx-I and CTx-II levels, n = 69 males) and VDR variables.


Males showed higher BMI and total MRI score than females. Patients bearing TT compared to tt VDR genotypes showed significant higher total MRI scores. Among males (n = 125), TT, bb and aa genotypes showed increased total MRI scores. Higher total MRI score directly correlates with higher levels of CTx-I and CTx-II (n = 69 males).


The markers previously identified as associated with the presence of EP lesions have been confirmed as related to their severity and could be used to follow the pathology progression.

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