Ximing Xu, Bin Zhang, Kaiqiang Sun, Jingchuan Sun, Yuan Wang, Chenglong Ji, Xiaoqiu Yuan, Peng Zhang, Yongfei Guo, Guodong Shi, Jiangang Shi


June 2020, Volume 29, Issue 6, pp 1219 - 1226 Original Article Read Full Article 10.1007/s00586-020-06381-z

First Online: 04 April 2020

Reliability and validity of multi-shot DWI in diagnosis of cervical spondylotic myelopathy: a study based on 3-T MRI

Objective

To investigate whether multi-shot diffusion-weighted imaging (ms-DWI) could be applied in diagnosis and quantitative evaluation of cervical spondylotic myelopathy (CSM).

Methods

Thirty-three normal volunteers and 78 patients with CSM were included in this study. The apparent diffusion coefficient (ADC) values were measured at C2–C7 levels on sagittal section ADC map. The intraclass correlation coefficient (ICC) and Bland and Altman plot and Spearman coefficient were used to quantify the reproducibility of test and retest and inter-rater reliability. Pearson correlations were calculated to compare lADC and rADC versus mJOA and NDI scores. Receiver operating characteristic curve and the area under the curve (AUC) were applied to evaluate the diagnostic reliability.

Results

There was no statistically significant difference between ADC values obtained from normal volunteers at C2–C7 levels (P 

Conclusion

The ms-DWI could be applied in diagnosis and quantitive assessment of CSM according to lADC and rADC. A new parameter, rADC, could be served as a diagnostic indice for CSM, which may quantitively reflect the severity of CSM.

Graphic abstract

These slides can be retrieved under Electronic Supplementary Material.[graphic not available: see fulltext]


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