Emre Acaroglu, Regis Bobe, Jocelyn Enouf, Ralph Marcucio, Florina Moldovan, Alain Moreau


June 2012, Volume 21, Issue 6, pp 1033 - 1042 Review Article Read Full Article 10.1007/s00586-012-2245-8

First Online: 09 March 2012

Objective

The purpose of this review is to elucidate the metabolic processes involved in the pathogenesis of adolescent idiopathic scoliosis (AIS) in light of research by the present authors as well as current literature.

Methods

Pathogenetic mechanisms involved in AIS were modeled as (a) a form of neuromuscular scoliosis (in conjunction with an adverse mechanical environment such as bipedality), in which hormonal and other chemical factors act as regulators of skeletal muscle tone and function; (b) as a consequence of an abnormality in growth of the spinal column (in conjunction with an adverse mechanical environment such as bipedality), in which hormones and other chemical factors act as regulators of growth; and (c) as a mechanical failure of one side of the vertebral column due to a defect in trabecular formation or mineralization (in conjunction with an adverse mechanical environment such as bipedality); in which hormonal and other chemical factors act as regulators of bone formation, mineralization and/or resorption.

Results and conclusion

Current evidence supporting these models individually or in combination is discussed.


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